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Clinical trials have demonstrated that PHIs can enhance HIF activity, offering the potential to alleviate diabetes-induced kidney hypoxia (48)

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With this method, the rate of CO production has been found to be increased severalfold from normal in patients with a variety of hemolytic anemias ( 162 ) and similarly elevated in conditions associated with ineffective erythropoiesis ( 243 )

10.1016/j.diabres.2016.04.046 78 SattarN.LeeM

GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone in the body that plays a crucial role in regulating blood sugar, appetite, and digestion