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Extracellular NAMPT (eNAMPT) is secreted from adipocytes and immune cells 43,44 via exosomes, and enters the circulation, allowing transport of this enzyme to other tissues

Cortisol changes sex hormone-binding globulin levels and can disturb local ovarian and testicular function through inflammatory and metabolic shifts

Meanwhile, mRNA levels of individual TET family members ( TET1 TET3 ) remained largely comparable between shCtrl and shGDH1 cells (Extended Data Fig

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No changes in fasting plasma levels of glucose or insulin have been observed