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Minimizing Nausea Nausea is the most frequently reported side effect of semaglutide

GLP-1 RAs are known to stimulate insulin and inhibit glucagon, effectively regulating body weight and glucose levels 13

Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism

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Clinical trials document headache incidence ranging from 515% depending on the medication, dose, and study population