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Humane endpoints were prospectively defined prior to study initiation and included sustained anorexia, marked body weight loss, persistent gastrointestinal disturbances, or other signs of clinical deterioration compromising animal welfare

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Patients with obesity may present with reduced CPT I levels leading to reduced levels of intracellular L-carnitine, which prevents them from using certain fatty acids for energy production, resulting in lipid accumulation in the cells especially in the adipose tissue and the liver [46,47]

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