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Moreover, the addition of -ketoglutarate (-KG), a metabolite derived from glutamate, effectively restored the viability of cancer cells with elevated levels of SLC7A11 during glucose deprivation, indicating a potential role for exported glutamate in promoting cancer cell death (59)

Haqq L, McFarlane J, Dieberg G, Smart N

Helpful Links References Arango, D., Morohashi, K., Yilmaz, A., Kuramochi, K., Parihar, A., Brahimaj, B., Grotewold, E., & Doseff, A

Immortalized cell lines are popular tools to study drug hepatotoxicity because they are cost effective, readily available as cryopreserved cells, can be of human origin and generally show robust proliferation

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