Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic
Other rare side effects that have been noted with these drugs include allergic reactions, gallstones (which can occur with a large amount of weight loss), and potential of medullary thyroid cancer (so far only documented in rats, not people), which is why they are contraindicated in people with Type 2 multiple endocrine neoplasia syndrome
Recent studies also highlight the role of perivascular adipose tissue (PVAT), which, when becoming dysfunctional and lipid-laden, loses its vasoprotective properties and secretes pro-inflammatory adipokines directly onto the adjacent arterial wall, creating a localized inflammatory milieu that accelerates atherosclerosis (38, 103) (As shown in Figure 4 )
Physical activity is also important for sustainable weight loss
Hyperglycemia is only one contributor
A dietitian weighs in on whether fiber can deliver the same benefits as weight loss medications