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While healthy NAD+ levels support mitochondrial health, it is MOTS-c that is more directly linked to promoting mitochondrial biogenesis (the creation of new mitochondria)

This randomised, double-blind, placebo-controlled trial enrolled 706 adults with overweight or obesity (BMI 27 or above) across multiple dose groups, running over 26 weeks

Note: not all the countries/places have easy access to compounding pharmacies

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It is advisable for those taking statins to also supplement with CoQ10