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Preclinical models indicate that GLP-1 receptor activation can influence the gut-brain axis as well as the hypothalamic-pituitary-adrenal (HPA) axis, with possible implications for stress regulation and energy homeostasis[11]

Modulatory role of dietary polyunsaturated fatty acids in nrf2-mediated redox homeostasis

doi: 10.1080/09513590.2019.1576622

Consistent with this, the recent ADA guidelines strongly recommend GLP-1RA use, particularly semaglutide 2.4 mg/week, as the preferred therapeutic option for adults with T2DM and MASH, or for those at high risk of advanced liver fibrosis (American Diabetes Association Professional Practice Committee for Diabetes*, 2025[2])

It has also been noted that MMNSTs typically grow along a spinal nerve root with a unique dumbbell configuration, though this is a nonspecific finding, as many types of tumors assume this configuration if they contain intradural and extradural components