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You may have found your optimal maintenance dose when: Weight loss is consistent at 0.5-1.0% per week Side effects are manageable and not significantly impacting quality of life Appetite is well controlled without feeling starved Energy levels are stable and adequate for daily activities and exercise Blood glucose and other metabolic markers are improving If these criteria are met at 8mg, there is no clinical obligation to push to 12mg

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Consistently with human BALF (Fig

Black circle added to the green indicates that these synthetic agonists have been slightly modified

Higher doses produced much better results, and all doses outperformed placebo by a wide margin