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Together, they allow for broader experimental observation

Association of the TLR4 gene with depressive symptoms and antidepressant efficacy in major depressive disorder

The primary research outcome was the severity of depressive disorder which was assessed using the second version of the Beck Depression Inventory-II (BDI-II), and a 50% reduction of the baseline BDI score was considered as the treatment response

Of particular significance is the remethylation of homocysteine ( Hcy ) to methionine, which not only detoxifies Hcy but also generates S-adenosylmethionine ( SAM )the universal methyl donor required for DNA methylation, neurotransmitter synthesis, membrane phospholipid remodeling, and creatine production

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