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These hormones play a key role in regulating appetite, digestion, and blood sugar levels

The anti-atherosclerosis and attenuated plaque formation effects of GLP-1 RAs are mediated through inhibiting the overall inflammatory response by suppressing the expression and release of proinflammatory cytokines (such as interleukin-6 and tumor necrosis factor-) and suppressing the activation of nuclear factor-kappa B signaling pathway (23, 24)

While copper allergy appears rare, patch testing could be prudent for patients with a history of metal sensitivity or atopic dermatitis

Here, they can typically last for 4-12 weeks

There were no observable trends in body weight (Supplementary Tables 6, 7) and no subjects tested positive for anti-drug antibodies post-treatment in either the single-dose or multiple-dose parts of the study