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BURKHART, BSDH, EdD, is an adjunct associate professor in the department of periodontics/stomatology, Baylor College of Dentistry and the Texas A & M Health Science Center, Dallas

The SASP secreted by senescent chondrocytes increases matrix metalloproteinase (MMP) activity, leading to the breakdown of cartilage and the progression of osteoarthritis

Legal status is variable, emphasizing cautious optimism over definitive claims

Environ Pollut 230:320328

doi:10.1111/acel.12950 Rossman MJ, Kaplon RE, Hill SD, et al

Persistent oxidative stress due to excessive ROS may cause a senescent state, an important hallmark of aging, resulting in inducing of cell growth delay 52