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A subsequent larger RCT (n=72) confirmed these findings, showing improvements in gait speed, grip strength, exercise capacity, waist circumference, and systolic blood pressure (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]

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At the same time, cells in the penumbra are subjected to periodical transient ischaemic depolarisations, 200 mechanisms of which are essentially similar to spreading depression