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For weight management, GLP-1 use generally applies to people who meet one of the following criteria: A BMI of at least 30 , or A BMI of at least 27, along with a weight-related condition like high blood pressure or high cholesterol Who shouldnt take tirzepatide or Wegovy

Moreover, this trial was conducted at a private practice and published in an alternative medicine journal, again raising concerns about bias

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Activation of GLP-1 receptors influences insulin secretion and satiety signaling, while glucagon receptor activation contributes to hepatic glucose output modulation and increased energy expenditure