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These findings suggest that the favorable effects of L-carnitine on chronic fatigue in patients with cirrhosis cannot be attributed to improvements in serum ammonia levels

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Thus, the concentration and bioavailability of these drugs in target tissues are increased

Moreover, TMAO increased the expression and activity of tissue factor (TF) via activation of the NF-B signaling pathway in primary human coronary artery endothelial cells (HCAECs), thereby promoting atherothrombosis (Cheng et al., 2019)

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