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Tirzepatide for T2D obesity SURMOUNT-2, weight -12.8/-14.7% at 10/15 mg, attenuated about 6-7 points vs non-diabetic obesity: Garvey Lancet 2023

So, while the debate between localized and systemic application will likely continue, the most consistent and logically sound approach for targeted ankle research points toward a localized, subcutaneous injection near the site of injury

S. Tanget al., TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair, Frontiers Media SA, Jun. 2021. doi: 10.3389/fcell.2021.670913

References U.S

Current subcutaneous injection technique job aid

Experimental data suggest a possible reduction in apoptotic signaling proteins and an increase in survival-related markers, hinting at a protective or growth-supportive role in cultured cells