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The authors wish to thank Jim Hogle, Ellie Ehrenfeld, Philip Minor and Jeff Almond for their support and invaluable scientific input

Lactate was considered a metabolic waste product with unfavorable effects

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Sections 4 m thick were prepared for HE staining ( 2.8 Serum metabolomics analysis 2.8.1 Sample preparation Take 100 microliters of serum and add 1000 microliters of extraction solution (methanol: acetonitrile: water = 2:2:1, volume ratio)