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Alzheimer's disease AD is a progressive neurodegenerative disorder characterized by the deposition of amyloid- (A) plaques and tau-associated neurofibrillary tangles, leading to synaptic dysfunction and neuronal loss (Figure 3A)

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A fund that invests in Underlying ETFs may provide returns that are lower than the returns that an investor could achieve by investing in one or more Underlying ETFs alone and the fund bears its proportionate share of each ETFs expenses, subjecting fund shareholders to duplicative expenses