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How to minimize the systemic effect while maximize the hepatic effect of in vivo administration of small molecules is an important problem before the large-scale clinical use

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doi: 10.3389/fphar.2014.00170 Received 01 May 2014 Accepted 30 June 2014 Published 16 July 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by George Anthony Oyler, Synaptic Research, USA

In clinical trials with participants with obesity, 5 mg, 10 mg, or 15 mg of tirzepatide once weekly provided substantial and sustained reductions in body weight over 72 weeks [22]

GHK-Cu naturally declines as we age