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doi: 10.1038/s41593-022-01183-6 173 KenigsbuchM.BostP.HaleviS.ChangY.ChenS.MaQ.et al

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As gestation advances, the placenta becomes increasingly vulnerable to xenobiotic agents because of decreases in placental thickness and a reduction in the number of cell layers

The Salk team discovered that senescent cells can transfer this ferroptosis vulnerability to neighboring healthy cells through acid ceramidase signaling, offering a novel metabolic target to selectively remove damaged cells and protect surrounding tissue