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doi: 10.1146/annurev-med-112311-083918 152 WangWGreenMChoiJEGijonMKennedyPDJohnsonJKet al

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8.1 Monoclonal anti-IGF-1R antibodies The primary approach entails employing anti-IGF-1R mAbs to impede ligand-receptor interactions, thereby inducing the internalization and subsequent degradation of IGF-1R

1B), and it may be that declining substrate availability is rate-limiting to NAD(P) + flux, providing a mechanism for the impact of NMN treatment on ovarian function and fertility