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Cyanopyrrolidines are one type of inhibitor that docks within the enzyme binding site through two critical interactions: First, a nitrile group forms reversible covalent bonds with the hydroxyl group of Ser630

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Further study on the brain injury model of mice induced by Cadmium (Cd) showed that L-theanine could protect mice from Cd-induced neurotoxicity, which was achieved by reducing the level of Cd in the brain and plasma, inhibiting the death of neurons in the cortex and hippocampus, improving the activities of SOD, GSH, and CAT in the brain, and most importantly, significantly alleviating the hyperphosphorylation of tau protein Ser199, Ser202, and Ser396 (26)