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The direct administration of microbiota-derived metabolites, such as short-chain fatty acids (SCFAs) and indole derivatives, has been shown in experimental models to improve insulin sensitivity, reduce inflammation, and promote gut hormone secretion, potentially bypassing the need for sustained microbial engraftment (112)

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This is ironic, because improved blood sugar control is one of the primary benefits of semaglutide

Duan Y, Prasad R, Feng D, Beli E, Li Calzi S, Longhini ALF, Lamendella R, Floyd JL et al (2019) Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency

doi: 10.4014/jmb.2207.07057