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N Engl J Med (2015) 373:224757

PATHOPHYSIOLOGY OF DKD Mechanisms of action SGLT2 inhibitors primarily act by blocking SGLT2 located on the luminal membranes of proximal renal tubules (S1 and S2 segments)

For a 150-pounder, thats 82 grams a day

Think of the hold time as the most important 2 to 5 minutes of your entire dosing routine

Impact of Increased Residual Gastric Content on Clinical Consequences By increasing the risk of RGC, the use of GLP-1 RAs can have negative clinical consequences on patient outcomes

Published in the New England Journal of Medicine in 2023, this phase 2 trial of retatrutide enrolled 338 adults with obesity