Several XO-inhibiting drugs are indicated for treatment of hyperuricemia and related disorders, such as gout, a painful condition characterized by deposition of monosodium urate monohydrate crystals in joints (Figure 12)
Getting treatment quickly can make a big difference
In addition, these studies show the lack of extracellular GSH and SCN may sensitize CFTR deficient cells to HOCl mediated toxicity
J Clin Lab Immunol
J Cell Physiol 230:30093018 Yu J, Shi YC, Ping F, Li W, Zhang HB, He SL, Zhao Y, Xu LL, Li YX (2021) Liraglutide inhibits osteoclastogenesis and improves bone loss by downregulating Trem2 in female type 1 diabetic mice: findings from transcriptomics
They support antioxidant defence while other treatments address pigmentation, texture or collagen decline directly