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These included: Anencephaly (underdeveloped brain and/or incomplete skull) Cleft palate Gastroschisis (a hole in the abdominal wall through which intestines or other abdominal organs may protrude) Narrowing of the aorta and other heart defects The study hypothesizes that birth defects caused by venlafaxine could result from the drug interfering with embryologic signaling pathways that rely on serotonin and norepinephrine

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5-HT3 receptors: role in disease and target of drugs

DOI:10.1016/s0022-3476(05)80306-3