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In medical terms, heartburn is often associated with acid reflux or gastroesophageal reflux disease (GERD) i.e

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Acid reaching the throat may cause irritation even without noticeable heartburn symptoms

An analysis of plasma metabolic mass spectrometry in children with asthma showed that Arg, Lys, and Met levels were significantly decreased in the susceptible asthma group compared to the non-susceptible asthma group