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The enzyme is expressed at high levels in red blood cells, which are easy to isolate and analyze, and the only vitamin-derived cofactor it requires is TPP

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Thus, both compounds are suitable for once-daily administration [2, 11]

Patel concurs and adds that every once in a while people who use his low-dosage (100 or 175 milligrams) topical treatment will experience a minor rash that quickly dissipates. These individuals should lower the dose to better suit their needs, he advises