Nail matrix melanoma Dermoscopic features of nail matrix melanoma include: Longitudinal brown to black parallel lines with irregular colouration, spacing, or thickness Disruption of parallelism, for example, pigmentation increases in width proximally Brown background Hutchinson sign: pigmentation of nail fold Nail plate fissuring or destruction These features are not entirely reliable and should not be used as a substitute for biopsy if there is any doubt about the origin of longitudinal melanonychia
Furthermore, access to GLP1-RAs is a major issue for uptake remaining relatively low despite the high efficacy of these medications (Rodriguez et al., 2025)
Last reviewed: June 18, 2026 Last updated: June 18, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
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W., Smith, R., ODwyer, S., Jacobs, D., Ziegler, T., & Wang, X
