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Out of 55 weeks, only 6 spent dieting

Interestingly, insulin decreased markedly from 15.610.4 to 9.34.2 (p = 0.000) in the EGCG group and from 17.014.8 to 12.37.5 (p = 0.039) in the placebo group

Note that the substantial weight loss from either GLP-1s or bariatric surgery is likely to have higher amounts of cost saving and QALY generation beyond the five years modeled in this study, as many of the complications of obesity are expressed later

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The trial demonstrated that semaglutide not only improved glycemic control but also reduced the risk of major adverse cardiovascular events (MACE), including nonfatal heart attacks and strokes