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After the model was expanded to include GS-H 2 Q adduct formation as a function of its reduction potential, it was then combined with the Reed glutathione model 21 in order to simulate how the quinone redox-metabolism of doxorubicin influenced the glutathione metabolism

doi: 10.1016/j.pharmthera.2016.07.015 112 VoglTLudwigSGoebelerMStreyAThoreyISReicheltRet al

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