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of Endocrinology and Internal Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark, 4 Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark, 5 Odense University Hospital, Steno Diabetes Center Odense, Odense, Denmark, 6 Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark, 7 Steno Diabetes Center North Denmark, Aalborg, Denmark, 8 Department of Clinical Pharmacology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark, 9 Steno Diabetes Center Aarhus, Aarhus, Denmark, 10 Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark, 11 Dept

doi: 10.1186/s12880-022-00939-7 133 ZhangQHuYHuJEDingYShenYXuHet al

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It has been shown to increase fat oxidation and energy expenditure by activating REV-ERB/ nuclear receptors, which are central to lipid metabolism and biological clock regulation

Acknowledgments The authors thank the Faculty of Medicine at Al-Quds University for academic support