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Heppner et al., 2015
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Th17-associated cytokines (IL-17, IL-22) stimulate ROS production in keratinocytes, making them more prone to ferroptotic death (192)
By the rational design of the biparatopic VNAR-D1 and C4, we improved this stabilization, resulting in several orders of magnitude enhancement in neutralizing potency and binding affinity 25
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