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Dikoma Shungu have demonstrated that the brains of ME/CFS patients feature severe glutathione depletion alongside ventricular lactate levels that are 300% to 350% higher than in healthy controls

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IF elicits AT stress response via adipocyte-autonomous p53 signalling The most potent mechanisms leading to macrophage recruitment in AT during obesity include stress-related pathways like apoptosis, senescence, and DNA-damage response 3