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The research, published on October 5, is the first large epidemiological study to focus on gastrointestinal issues in nondiabetic patients who use these medications for weight loss

The observed non-significant increase in TSH levels is likely a compensatory response to decreased circulating levels of T4 and T3

It requires further investigations and prospective clinical trials by the scientific world for an increased understanding of pharmacogenomics, biomarkers, and clinical features that identify subpopulations of patients who will best respond to specific medications to provide care tailored to individual patients

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