However, this primarily reflects a lack of systematic investigation rather than confirmed safety
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Calorie restriction appears to affect neurobiological pathways that control appetite, hunger, cravings and body weight, such that there is increased food intake and weight gain (Brown et al, 2022)
[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Tong G, Peng T, Chen Y, Sha L, Dai H, Xiang Y, et al
Not at first, but they eventually relented
Leaving Retatrutide at room temperature initiates degradation