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Freezing can damage the delicate protein structure of semaglutide and cause crystallization, which reduces bioavailability when you inject it

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Patients with a history of anxiety disorders may require closer monitoring or modified dose escalation protocols

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When used with insulin or sulfonylureas, it can cause low blood sugar levels

10.3390/antiox11020428 23 CrnkovicS.Thekkekara PuthenparampilH.MulchS.BiasinV.RadicN.WilhelmJ.et al (2025)