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GLP-1 RAs exert direct and indirect effects on the CV system including vasodilation, natriuresis anti-atherosclerotic effects, improvements in endothelial function, anti-inflammatory effects (decrease cytokines level such as tumor necrosis factor, interlukin-1, interlukin-6) and a consequent decrease in C-reactive protein, and reductions in infarct size (60, 84, 85)

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These arent independent mechanisms but parallel outputs from the same receptor activation event

When to Seek Medical Advice About Digestive Symptoms Seek urgent medical attention for chest pain, vomiting blood, severe abdominal pain, or black stools

The two-week start takes the guess work out of what to eat

Contact your GP or diabetes specialist nurse to discuss adjusting the doses of any other diabetes medications you are taking, as dose reductions may be necessary to prevent recurrent hypoglycaemia