Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks
Clinically, these outcomes are comparable
There were also reductions in tau, a protein that creates harmful tangles in neurons that is also considered a marker of Alzheimers disease, in 19 of the studies
Aureli, A., Recupero, R., Mariani, M., Manco, M., Carlomagno, F., Bocchini, S., Nicodemo, M., Marchili, M
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