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In the semaglutide-treated cohort, early weight loss at 20 weeks did not predict subsequent cardiovascular outcomes, whereas greater reductions in waist circumference were associated with lower MACE risk at both 20 and 104 weeks

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Tirzepatide joins a similar medication called semaglutide that was also initially developed for diabetes treatment under the name Ozempic and has since been approved to treat obesity under the name Wegovy

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If the remaining trials produce positive results, Eli Lilly is expected to submit a New Drug Application (NDA) to the FDA in late year