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The semaglutide cohort ( n = 1470) compared with the non-GLP-1RA anti-obesity medications cohort ( n = 2784) was older, included more women, had a higher prevalence of severe obesity and obesity-associated comorbidities including T2DM and lower prevalence of adverse socioeconomic determinants of health, mental disorders, and substance use disorders

While the injection shows slightly higher average weight loss, the difference is modest

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