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Common side effects include nausea, vomiting, diarrhea, and constipation, typically mild and temporary

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The dizziness some people experience on semaglutide can become severe with accidental double dosing

However, gastrointestinal intolerance (notably nausea and vomiting in up to 73% of participants) and a single confirmed case of drug-induced liver injury led Pfizer to discontinue development in April 2025, highlighting the delicate balance between oral potency and hepatic safety in this drug class (149)

Tchetina EV, Markova GA, Poole AR, Zukor DJ, Antoniou J, Makarov SA, et al