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Typical effective dosing: The dosing is specific to each patient based on weight, what the injection is being used for, and tolerance to the injection

An interesting therapeutic strategy is to induce arginine transporters (e.g., Slc7a2) in antitumor T cells, before their adoptive transfer to patients, enhancing their ability to compete for arginine in the TME, without the deleterious effects of arginine depletion for antitumor immunity [8]

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However, a limitation of that study was that the number of subjects considered was very small [130]

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Future research needs to continuously deepen the mechanistic analysis of the HIF-ROS interaction network to optimize therapeutic strategies based on redox homeostasis