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Youn GS, Lee KW, Choi SY, Park J (2016) Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kappaB/AP-1 signaling pathways in macrophages

When not paired with protein and exercise, rapid weight loss can increase your risk of sarcopenia (the loss of skeletal muscle mass and strength)

Damian Holsinger, The University of Sydney, Australia Reviewed by Tianlu Chen, Shanghai Jiao Tong University, China

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Provide your medical history, current medications, and weight loss goals

Practical strategies include ensuring adequate caloric and protein intake, wearing thermal layers with attention to extremities, engaging in regular physical activity to maintain metabolic rate, and maintaining ambient temperatures of at least 18C