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High doses (over 4 g per day) are not recommended as they can cause gastrointestinal complaints (e.g

Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van Someren EJ

Using DHEA over a long period or at high doses may be associated with cancer, and short-term use at low doses may lead to side effects such as acne, insomnia, mood changes, headache, and stomach upset

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If you experience persistent heart palpitations, you should always consult a healthcare professional

A 2025 systematic review published in Orthopaedic Journal of Sports Medicine examined BPC-157 in the context of musculoskeletal healing, noting its preclinical activity across fractures, tendon, and ligament models