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In Arabidopsis, the P450-type MAX1 enzyme converts carlactone to the intermediate methylated carlactonic acid, which binds to the SL receptor /-hydrolase D14 177

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Beyond muscle growth, its regenerative properties could be helpful in wound healing and anti-aging research

Remethylation requires folate and B12 coenzymes, while transsulfuration requires pyridoxal-5-phosphate, the B6 coenzyme

10.1089/acm.2006.12.881 Summary Keywords vitamin B12, efficacy, bioavailability, therapeutic approaches, meta-analysis, cobalamin Citation Mazur M, Ndokaj A, Salerno C, Vallone J, Ardan R, Bietolini S, Carrouel F, Wilk A, Sarig R, Ottolenghi L and Bourgeois D (2025) Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

Sacco R, Eggenhoffner R, Giacomelli L