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Consistent with our previous observations using native GLP-1 and GLP-1 receptor agonists, incubation of INS-1 cells with Exendin-4-Fc resulted in concentration-dependent effects on insulin release (MacDonald et al

In SUSTAIN-6, semaglutide treatment reduced the risk of MACE by 26% in a short follow-up duration (median 2.1 years)

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These include: dizziness headache nausea flu-like symptoms hives increased heart rate flushing hyperactivity redness and tenderness at injection site difficulty swallowing Possible adverse effects are the reason that all peptide therapies should be conducted under the supervision of a qualified physician

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