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Expected 12-month results include 15 to 20% body weight loss (65 to 100+ pounds for a 400-pound person), 6 to 10 inch waist circumference reduction, transformative improvement in daily functional capacity, and resolution or significant improvement of multiple obesity-related conditions

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The evidence that exists is indirect, drawn from switching studies, pharmacological principles, and real-world clinical observations

Mayaro virus infects human chondrocytes and induces the expression of arthritis-related genes associated with joint degradation

doi:10.1016/j.sleh.2014.12.010