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Similarly, a reduction in the cross-conservation of the frame 5 promiscuous and cross-conserved epitope in the API might lead to increased immunogenicity in vitro and in vivo , as discussed in greater detail below

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It is not typically fatal

Die verffentlichten klinischen Studien berichten ber eine ausgezeichnete Hautvertrglichkeit, ohne signifikante Reizung oder bemerkenswerte allergische Reaktion bei den in topischen Formulierungen verwendeten Konzentrationen (blicherweise 0,01 % bis 1 %)