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Combining it with another GLP-1 or GIP agonist (semaglutide, tirzepatide) would compound the same receptor load and the same GI and hypoglycemia risks with no efficacy evidence to support it

Its main role is to transport fatty acids to the mitochondria, where they are used to produce energy

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Validating robust, non-invasive biomarkers (e.g., circulating lipid peroxide metabolites, urine exosomal ferroptosis regulators, or TME-derived immune cell ferroptosis signatures) is urgently needed to guide clinical trial design and patient stratification

The peptides role in enhancing interactions with dopaminergic, serotonergic, and opioid systems also suggests potential applications in treating neurodegenerative disorders such as Parkinsons disease, where these neurotransmitter systems are often compromised